Recent Research Highlights

The left panel corresponds to an artistic collage, showing Spo11-complexes (blue and yellow shapes) that cleave pieces out of chromosomes (shown in black). Red halos depict DNA-damage signalling. Liberated pieces carry a part of the Spo11-complex on each end. The right panel shows observed chromosomal break sites at a meiotic recombination hotspot. Each arc labels start and end of an isolated fragment coming from a different cell. Wild-type fragments are in red, fragments from a mutant that doesn’t degrade longer fragments, are in blue. (c) Franz Klein, Chromosomenbiologie, Universität Wien

Meiosis: Mind the gap

Meiosis is a specialized cell division process required to generate gametes, the reproductive cells of an organism. During meiosis, paternal and…

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A groundbreaking genetic screening tool for human organoids

Researchers from the laboratory of Jürgen Knoblich at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – developed…

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Autophagy: the beginning of the end

Autophagy, from the Greek for ‘self-eating’, is an essential process that isolates and recycles cellular components under conditions of stress or when…

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Detective work in the cell: Scientists uncover a new RNA-modifying enzyme

Scientists led by Javier Martinez from the Max Perutz Labs, a joint venture of the Medical University of Vienna and the University of Vienna, have…

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How the immune system generates a vast antibody repertoire to fight infections

It is long known that the acquired immune system can generate a vast antibody (immunoglobulin) repertoire by gene recombination in developing B-cells.…

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Layered Liquids – reaction chambers for gene regulation

A marvel of complexity, the nucleus is the command center of the cell – harboring information, codes and controlled access. But different from…

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Cross-resistance: when cancer therapy backfires

Scientists at the IMP and collaborators have investigated how different forms of cancer therapy can influence the efficacy of subsequent therapies.…

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Disrupting ribosome production – renewed potential for cancer therapy

Proliferating cells are in constant need of ribosomes, the molecular machines that help them produce proteins. Tumour cells, for instance, divide…

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A new role for histone modifications in genomic imprinting

Imprinted genes are expressed from either the paternal or maternal allele. Reporting in Nature Communications, scientists led by Martin Leeb have now…

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Colouring tumours reveals their bad influence

Red2Onco, an innovative genetic mouse model, allows to detect the very initial steps that lead to cancer development. Red2Onco’s multi-colour…

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Cardioids – Heartbeat, heartbreak and recovery in a dish

Self-organizing heart organoids developed at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – are also effective…

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Lockdown for genome parasites

Researchers at GMI – Gregor Mendel Institute of Molecular Plant Biology of the Austrian Academy of Sciences – uncover an ingenious mechanism by which…

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