Scientists at the Vienna BioCenter are using bottom-up approaches to discover how individual molecules assemble into sophisticated 3D structures that perform highly specialized cellular functions. By combining biochemistry research, biophysics research, and state-of-the-art structural methods, scientists are resolving macromolecular complexes at atomic resolution, reconstituting multi-component complexes in vitro, studying protein-ligand interactions, and observing molecular machines in action.Read more
To get fundamental insights into how a cell, the basic unit of life, is organized and divides, a highly interactive research community at the Vienna BioCenter uses cutting-edge approaches, including super-resolution microscopy, high-content screening, biochemical reconstitution, and genomics, to functionally dissect the molecular biology of the cell.
To understand the vast complexity in biology, many research projects at the Vienna BioCenter have integrated algorithm development, modeling, and high-throughput processing of data. These computational tools enable the next-level analysis of large amounts of biological data, ranging from high-throughput microscopic images to genome sequences or thousands of single-cell transcriptomes, and are also indispensable for evolutionary biology research.Read more
Exploiting the wide range of expertise and model systems at the Vienna BioCenter, researchers ask how certain mutations lead to disease, how organisms defend themselves against pathogens and malignant cells, and how we can use this knowledge to develop better therapeutics and improve agriculture.
Research in gene regulation and gene expression, RNA biology, and epigenetics at the Vienna BioCenter combines diverse approaches ranging from biochemistry and cell biology to genomics and transcriptomics to unravel the connections between genomes and the transcripts they encode. A particular focus is on RNA research, where myriad roles for this nucleic acid have only recently come to light.Read more
The Vienna BioCenter is highly respected in the Vienna neuroscience scene as well as the global neurobiology community, and uses state-of-the-art techniques to address fundamental questions in the field. How do brains form and evolve? What are the molecular mechanisms that process and store information? How do activity patterns in neural circuits produce perception and behavior? And what mechanisms underlie neurological disorders?Read more
Scientists at the Vienna BioCenter are using their cutting-edge research infrastructure to uncover the signaling steps and regulatory mechanisms that control tissue, organ, and organismal development. This area of research has enormous biological and medical relevance, providing insights into developmental diseases and cancer, as well as tissue and organ regeneration.Read more