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Image shows the distal part of the C. elegans gonad in wild type and the ppm-1-D mutant. CYE-1 (in magenta) marks the progenitor cell zone (which contains stem cells and progenitor cells undergoing mitosis). Phospho-SUN-1 (in green) labels the nuclear envelope after meiotic entry In the wild type the two markers are mutually exclusive, note in ppm-1.D mutants there is an overlap in a couple of cell rows. (c) Baudrimont et.al 2022

Keeping meiotic entry in check

The differentiation of germline progenitor cells into meiocytes is crucial for the production of healthy gametes. In C. elegans, this step is governed…

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How a small RNA pathway talks to the heterochromatin machinery

Inaugurating the #ScienceChatIMBA series: Group Leader Julius Brennecke, graduate student Veselin (Ves) Andreev and postdoctoral fellow Changwei Yu…

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Aiming for the basket

The nuclear pore basket is a conical, net-like structure that is attached to the main body of the nuclear pore complex. The basket is crucial for the…

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Moritz Gaidt to study innate immunology at IMP

Moritz Gaidt, previously a postdoctoral researcher at the University of California in Berkeley, has joined the IMP as a group leader. The Gaidt Lab…

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ERC grant for Thomas Juffmann

The European Research Council ERC has awarded a Proof of Concept grant to the group of Thomas Juffmann. Following up on an ERC Starting Grant in 2018,…

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Blooming too soon: timing is crucial to error-free cell division

The Bloom (BLM) DNA helicase is an important enzyme in DNA repair and the maintenance of genome stability. Mutations in BLM are associated with…

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Stay positive – how the brain incites mice to react positively to both fear and reward

Neuroscientists used to think that positive and negative emotional states were processed in distinct areas of the brain. Mounting evidence from the…

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Azelastine - the active drug in anti-allergy nasal sprays demonstrated to have potent anti-viral effect on the Omicron variant of SARS-CoV-2

CEBINA GmbH announced new results demonstrating that azelastine, the active drug in Pollival®, URSAPHARM’s widely available anti-allergy nasal spray,…

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Curb your enthusiasm: scientists find key to self-control

Scientists from the lab of Wulf Haubensak and collaborators characterised brain functions that are key to reining in impulsive behaviours. Studying…

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Not all brains are equal: Why the human brain is more vulnerable to disease

With the help of cerebral organoids, IMBA scientists were able to ascertain that Tuberous Sclerosis, a rare neurodevelopmental genetic disorder,…

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Of inclusive science and exceptional mentoring: science communication award for Victoria Deneke

In 2020, the Society for Developmental Biology launched their Trainee Science Communication Award to recognise the outreach and mentoring efforts of…

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IMP students characterise a sperm protein essential for zebrafish fertilisation

During fertilisation, egg and sperm rely on a host of membrane proteins to bind and fuse. Two students at the IMP examined the function of Spaca6 – a…

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