Sperm's creative approach to genome packing

A team of researchers around IMP Scientific Director Jan-Michael Peters investigated DNA folding in a highly specialized cell type: sperm. Their study, published in the journal Genome Research, reveals a distinct three-dimensional genome organization that folds DNA very densely, setting vertebrate sperm apart from other cell types. The findings prompt further exploration into the role of certain proteins in shaping the sperm genome.

Human sperm, visualised with a light microscope (credit: IMP)

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