New insights into how B cells time the duplication of their genome

In humans, two meters of DNA must be replicated and evenly shared between newly divided cells during every cell cycle. While some regions are duplicated early, others must wait their turn. In a study now published in Nature Communications, scientists in the lab of Rushad Pavri at the IMP investigate the protein RIF1 and its unique role in regulating the timing of DNA replication in B cells.