Cohesin, a ring-shaped protein complex, tethers the two DNA copies contained in each replicated chromosome such that they can be properly moved during cell division. A subset of cohesin complexes, known for its ability to extrude DNA loops, also facilitates the separation of duplicated DNA molecules, a new study by the Gerlich lab at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - shows. These findings support the notion that DNA loop extrusion is an evolutionarily conserved mechanism, promoting the segregation of replicated genomes into daughter cells.
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