Recent Research Highlights

Inside the cell’s recycling hub: unveiling the architecture of UBR4

Researchers from the lab of Tim Clausen and collaborators have unveiled the three-dimensional structure of UBR4, a giant protein complex that…

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ZNFX1 compacts and tags RNA to keep immunity in check

Tim Clausen’s lab at the IMP and collaborators have uncovered how the ancient immune protein ZNFX1 enables cells to walk the fine line between…

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Reading more than a 1000 genomes: a long-read map of human diversity

Structural variants—large genomic changes like insertions, deletions, and duplications—are one of the main sources of human genetic diversity and can…

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Hand2: positional code that allows axolotls to regrow limbs found

With its fascinating ability to regrow entire limbs and internal organs, the Mexican axolotl is the ideal model for studying regeneration. Scientists…

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Rules of engagement: How DNA remodelers shape mitotic chromosomes

Molecular motors package and rearrange the DNA so that the long and tangled strands are safely divided into the daughter cells. A new study describes…

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First snapshot of retrotransposon in action

For the first time, scientists have visualized a retrotransposon, a “jumping gene” , inside the cell of a complex organism. Advanced cryo-Electron…

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A turning point for cancer treatment: monocytes boost T-cells in immunotherapy

Scientists led by Anna Obenauf at the Research Institute of Molecular Pathology (IMP) now discovered the crucial role of a type of immune…

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Beginning of life: molecular "lock-and-key" of fertilisation found

Genetic studies have identified many proteins that contribute to the first contact between egg and sperm. However, no direct evidence has yet…

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Scientists Discover "Pause Button" in Human Development

Researchers at the Max Planck Institute for Molecular Genetics and the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences…

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Unlocking the disassembly of a molecular editor

Researchers led by Clemens Plaschka at the Research Institute of Molecular Pathology (IMP), were able to visualise the disassembly of the spliceosome…

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Revealing the evolutionary origin of genomic imprinting

Some of our genes can be expressed or silenced depending on whether we inherited them from our mother or our father. The mechanism behind this…

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Artificial Intelligence cracks code of gene regulation

Organisms are built from thousands of different proteins, each of them encoded by a specific gene. For a cell type to acquire its unique identity,…

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