COHESIN

The role of novel post-translational modifications of the cohesin

 

  • Duration: January 2018 – December 2021
  • Funded by:  FWF
  • Programme: FWF Stand Alone
  • Total project costs: € 399,557

 

Meiosis is a specialized cell division that produces gametes (e.g., egg and sperm cells) that contain only half the number of chromosomes of the parent cell. Meiosis is thus essential for all sexually reproducing organisms. Although we know many details about meiosis, we are far from a thorough understanding. Cohesin is a protein complex that has several essential roles during meiosis. Our recent analysis showed that, during meiosis, methyl groups are added to cohesin. We know from previous studies that protein methylation is an important mechanism that regulates protein function. In this project, we want to decipher the role of cohesin methylation using the fission yeast Schizosaccharomyces pombe as a model organism. We believe that this will help us understand how cohesin functions and provide important insights into the mechanism of chromosome segregation during meiosis.