Win some – lose some: how cells adapt to aneuploidy

An abnormal number of chromosomes, known as aneuploidy, is a common feature of many human cancers. Most cancer types harbor specific patterns of these chromosomal abnormalities, but why certain chromosomes are selected for gain or loss while others are not is poorly understood. In work published in Genes & Development, the lab of Christopher Campbell has now managed to recapitulate some of the aneuploidy patterns seen in cancer cells in the lab. They were able to identify specific genes that are responsible for the selection of certain aneuploidies for the first time in human cells.

(c) Christopher Campbell and Tamara Klockner

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