Unlocking the disassembly of a molecular editor

Researchers led by Clemens Plaschka at the Research Institute of Molecular Pathology (IMP), were able to visualise the disassembly of the spliceosome at unprecedented detail, revealing that ‘multi-factor authentication’ is required to initiate the process. Their findings were published in the journal Nature.

Researchers from the lab of Clemens Plaschka at the IMP in collaboration with the lab of Luisa Cochella, IMP adjunct investigator at the Johns Hopkins School of Medicine, have now shown at unprecedented detail how the spliceosome disassembles. The scientists achieved this feat by combining cutting-edge cryo-electron microscopy (cryo-EM) with biochemical and genetic data. Their findings are now published in the journal Nature.

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