The hidden DNA code behind a powerful antiviral response

Cells rely on powerful alarm systems to detect and stop viral infections—but these systems must be kept under tight control to avoid damaging healthy tissue. Researchers from the lab of Moritz Gaidt at the IMP have now identified a new gene regulatory mechanism that keeps immune responses restrained while remaining ready for rapid activation. Combining experimental biology and machine learning, the team discovered a cluster of specific DNA motifs within repetitive DNA that acts as a powerful immune switch capable of strongly amplifying inflammation. Their findings are published now in The EMBO Journal.