B-cells are vital white blood cells responsible for producing antibodies to fight off infections in our body. Their development is tightly regulated by several transcription factors that activate the genes needed to guide them through the sequential stages of maturation. The exact role of each transcription factor has remained unclear due to several limitations in current methods, such as gene knockouts, which are constrained by the essentiality of these genes. Researchers from Meinrad Busslinger’s lab at the Research Institute of Molecular Pathology (IMP) now employed a new tool to target protein elimination in live mice and observed how these factors directly influence gene activity. Their findings are published in the journal Nature Immunology.
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Targeted protein breakdown in mice reveals new insights into B-cell development
