Strength in numbers: how weak enhancers can be powerful gene regulators

mRNA expression of Fgf5 (red) and Otx2 (yellow) in mouse EpiLCs. (c) Christa Buecker, Max Perutz Labs
mRNA expression of Fgf5 (red) and Otx2 (yellow) in mouse EpiLCs. (c) Christa Buecker, Max Perutz Labs

How multiple enhancer elements cooperate to drive expression of their target gene is poorly understood. New research from the lab of Christa Bücker shows how a group of enhancers with weak individual activity can work together to induce robust transcription of a gene. The study is published in Molecular Cell.

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