Seeing proteins fold as they are being made

As ribosomes build new proteins, folding begins while the protein emerges. By capturing a chaperone, a helper protein, bound to a ribosome, researchers from the lab of David Haselbach and collaborators reveal the entire picture of how chaperones guide this cotranslational protein folding in yeast.

Detailed 3D view of a eukaryotic ribosome (80S) with Ssb attached, revealing how helper proteins support protein synthesis.

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Original publication

Ying Zhang, Lorenz Grundmann, Leonie Vollmar, Julia Schimpf, Volker Hübscher, Mohd Areeb, Irina Grishkovskaya, Anna Moddemann, Kerstin Werner, Thorsten Hugel, David Haselbach and Sabine Rospert (2025): „The cotranslational cycle of the ribosomebound Hsp70 homolog Ssb“. Nature Communications (2026). DOI: https://doi.org/10.1038/s41467-025-67685-6.

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