Scientists show how cells build protein destruction signals

Scientists at the IMP and international collaborators have investigated how unwanted proteins in the cell are tagged for degradation. By combining state-of-the-art microscopy and sophisticated deep learning techniques, the team provides valuable insights into the choreography that governs protein regulation. The results of their study, published in the journal Nature Structural and Molecular Biology, shed light on previously unseen molecular processes.

Maps of the structural dynamics of APC/C-dependent ubiquitination, created using neural networks (credit: authors)

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