A kinase goes into the recycling business

RAF1 is best known as a key signal transducer in the mitogen-activated protein kinase (MAPK) pathway, where it controls cell proliferation and survival. Emerging evidence, however, suggests it may have additional, unexpected roles. In a new study published in Cell Reports, PhD student and first author Stefanie Toifl (Baccarini lab) uncovers a surprising function: together with newly identified substrates, RAF1 is required for efficient autophagic lysosome reformation.