Putting a Lid on Multidrug Resistance

Transport cycle of the human ABCG2 drug transporter, (c) Narakorn Khunweeraphong und Karl Kuchler

Multidrug resistance (MDR) is a fundamentally important medical phenomenon that undermines anticancer and anti-infective therapy of cancer or infectious diseases. Researchers of the Max Perutz Labs, a joint venture by the Medical University of Vienna and the University of Vienna, have delineated the molecular mechanism, whereby the human ABCG2 drug transporter drives MDR. The results suggest new therapeutic strategies to prevent MDR by inhibiting the ABCG2 transporter.

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