Punching holes in the nucleus

Nuclear pore complexes (NPCs) are the gateways between the nucleus and the cytoplasm. How the individual components assemble into a functional pore is not understood. In a new study, published in Nature, Max Perutz Labs group leader Shotaro Otsuka and the lab of Jan Ellenberg (European Molecular Biology Laboratory, EMBL) provide the first step-by-step guide to NPC assembly. In the future, their approach could be applied to investigate the assembly mechanisms of other molecular machines in the cell.

Assembly of the nuclear pore complex over time. Credit: EMBL/Isabel Romero Calvo

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