Profiling the stem-cell characters in the story of stomach lining renewal

15 Aug'19

Using an unbiased labelling technique, mathematical modelling, and single cell profiling to trace the footsteps of stem cells and their daughters, researchers at the University of Cambridge (UK), DGIST (S.Korea), and IMBA (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria) have confirmed that two populations of adult stem cells with distinct roles and characteristics reside in the glands of the stomach.

Described in the current issue of Cell Stem Cell, a joint team lead by Dr Bon-Kyoung Koo at IMBA and Prof Ben Simons at the University of Cambridge has applied a unique approach – the multi-colour mouse confetti reporter system - to map the movements and trace the origins of cells in the mouse stomach directly.