Ezra Levy, Andrea Pauli Lab
His project investigates how the developmental programs for sperm and eggs are established during early zebrafish development. In many animals, the instructions that define future egg and sperm cells are stored in a specialized structure in the egg known as germplasm, a molecular compartment containing RNAs and proteins. However, how these maternal components are activated over time to guide germline development remains poorly understood.
With this funding, Ezra Levy will study how germplasm changes over time during early development and how its stored genetic information is activated step by step to guide germline formation. Using a combination of molecular profiling and imaging approaches, the work aims to reveal how the embryo controls the timing of germline development. Beyond providing new insights into reproduction and early development, the findings may also help uncover general principles of how cells organise and regulate key biological processes.
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