Wild-type Sgk3 (red) localizes to PI3P-decorated endosomes in HeLa cells. Sgk3 mutated in its PI3P binding site (green) localizes throughout the cytoplasm. Pokorny et al., Journal of Biological Chemistry (2021)

Signal transduction: In the right place, at the right time

Cells integrate internal and external stimuli through complex signaling pathways in order to adapt to changing environments. In particular, cells must…

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Cross-resistance: when cancer therapy backfires

Scientists at the IMP and collaborators have investigated how different forms of cancer therapy can influence the efficacy of subsequent therapies.…

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Valneva Awarded FDA Breakthrough Designation for its Single-Shot Chikungunya Vaccine Candidate

Valneva announced that it has been awarded Breakthrough Therapy Designation for its single-shot chikungunya vaccine candidate, VLA1553, by the U.S.…

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Boehringer Ingelheim awards the Grass Roots Innovation Prize to a:head bio AG

a:head grows cerebral organoids in culture to conduct research into therapeutics for central nervous system disorders. The company is the second…

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Valneva to Host Symposium on COVID-19 and Chikungunya Vaccine Candidates at 31st European Congress of Clinical Microbiology & Infectious Diseases

Valneva announced it will host a virtual symposium titled, “Developing new vaccines to protect against infectious diseases at home and abroad” on July…

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Hitting the right note in dialysis care

Patients with malfunctioning kidneys often need dialysis to rid their blood of unwanted molecules and excess water. Personalising the settings of…

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Luis Miguel Cerron Alvan (l), Helena Bragulat Teixidor (r), (c) Max Perutz Labs

Max Perutz PhD Fellowships

Luis Miguel Cerron Alvan and Helena Bragulat Teixidor have been selected as the first Max Perutz PhD Fellows. The program was established earlier this…

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Profiling gene expression in plant embryos one nucleus at a time

The first plant embryo gene expression atlas at the single cell level was developed by a team of researchers at GMI – Gregor Mendel Institute of…

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Top left, allele-specific RNA-Seq performed on pre-implantation blastocysts from reciprocal mice hybrids to identify parent-of-origin specific gene expression; top right, genome-wide methylation analysis performed on uniparental haploid blastocysts to identify DNA methylation regions that are differentially methylated between the maternal and paternal genomes.  Bottom: H3K27me3-dependent imprinting has a major impact at the pre-implantation blastocyst stage, especially for the "transient" novel imprinted genes in contrast to the more prominent role for DNA methylation-dependent imprinting at later developmental stages for canonical imprinted genes

Hot off the press: a new role for histone modifications in genomic imprinting

Imprinted genes are expressed from either the paternal or maternal allele. Reporting in Nature Communications, scientists led by Martin Leeb have now…

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Helena Bragulat Teixidor (back, left), Dana Abdeen (back, right), Daria Filipczak (front, left), Aleksandra Anisimova (front, right). (c) Max Perutz Labs

ÖAW DOC Fellowships for Max Perutz Labs students

The Austrian Academy of Sciences (ÖAW) has awarded four DOC fellowships to Max Perutz Labs PhD students Dana Abdeen, Aleksandra Anisimova, Daria…

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CEBINA announces the launch of Danube Labs

CEBINA announced the launch of Danube Labs, a partnership with Evotec SE to fast-track early-stage academic research to drug discovery and…

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Amygdala: a piece in the puzzle of pain

The almond-shaped brain region amygdala is a key regulator of fear and reward – with a wealth of associated emotions. An international team of…

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