Net zero – using a basket to control enzymatic activity

Faithful chromosome segregation during meiosis depends on the spatial and temporal coordination of dramatic changes in cellular and subcellular architecture. In a new study published in Cell Reports, first author Rahel Wettstein from the Matos lab has uncovered an unexpected role for the nuclear pore complex in controlling crossover formation through regulation of SUMOylation dynamics in yeast. By linking nuclear pore basket components to the localization of a SUMO protease, the work reveals how nuclear architecture shapes meiotic recombination outcomes.