Meet MutLγ: a rising crossover star

Meiotic crossing-over is a fundamental process in sexual reproduction that reshuffles genetic information between homologous chromosomes and ensures their correct segregation. In a new study published in Nature Communications, first author Lucija Orlić from the Matos lab dissects how different DNA repair enzymes resolve recombination intermediates and uncover a previously unknown structural role for the enzyme Top3 that is essential for their resolution into crossovers.