In the right place, at the right time

The precise orchestration of cellular processes requires proteins and other macromolecules to be organized in space and time. While working in the lab of Manuel Leonetti at the Chan Zuckerberg Biohub, San Francisco, first author Marco Hein and Biohub colleagues mapped the subcellular distributions of more than 7,600 human proteins. Using a viral infection model, the authors then showed that many proteins are regulated by changes in their subcellular localization rather than by changes in their abundance. The study, published in Cell, is the culmination of research Marco conducted during his work as a Biohub fellow.