How to detox the nucleus of unsaturated fat

In eukaryotes, the nucleus harbors the genetic information of a cell, protected by a double lipid membrane called the nuclear envelope. The lipid composition of membranes is tightly regulated, thereby controlling its biophysical properties and functionality. In work published in Developmental Cell, Anete Romanauska and Alwin Köhler have discovered a detoxification mechanism that protects the inner nuclear membrane from high concentrations of unsaturated lipids that can alter the viscosity and function of the envelope. They have delineated the mechanism by which excess unsaturated fatty acids are stored in cytoplasmic lipid droplets and thus kept away from the nucleus.

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