How the genome is packed into chromosomes that can be faithfully moved during cell division

Researchers from the Gerlich Group at IMBA discovered a molecular mechanism that confers special physical properties to chromosomes in dividing human cells to enable their faithful transport to the progeny. The team showed how a chemical modification establishes a sharp surface boundary on chromosomes, thus allowing them to resist perforation by microtubules of the spindle apparatus. The findings are published in the journal Nature.

Organization of mitotic chromosomes and spindle microtubules at an early phase of cell division. ┬ęGerlich/IMBA.

Read the full #ScienceChatIMBA interview with Daniel Gerlich here.