New insights into the self-organisation and regeneration of tissues | Researchers at the University of Vienna have discovered a key mechanism that enables sea anemones to regenerate into a fully developed organism from disorganised clusters of cells. The study, published in Nature Communications, shows that the so-called Notch signalling pathway controls tissue organisation and the formation of the body axis. The findings provide new insights into the fundamental rules of biological self-organisation and could help us better understand how tissues form, organise themselves and regenerate following disruption.
Animal development follows genetic programmes that control the formation of cells, tissues and body structures. At the same time, these processes are often remarkably robust: at least some organisms are able to restore their ordered body organisation even after significant disruptions. How this capacity for self-organisation is controlled at the molecular level is as yet only partially understood.
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