In an international collaboration, researchers around David Haselbach at the Research Institute of Molecular Pathology (IMP) have investigated how the proteasome, the cell’s waste disposal machine, distinguishes between different molecular labels to decide a protein’s fate. By using cutting-edge cryo-electron microscopy and precisely engineered molecular labels, the team captured the first high-resolution view of the human proteasome as it reads different destruction signals. Their findings, published as a preprint on bioRxiv, shed light on how the proteasome makes its life-or-death decisions for cellular proteins.
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How cells decide on the life or death of a protein
