NIAID has made a base award of $215,093 with a total contract value of $20.6 million if all contract options are exercised. The contract options are staged along milestones, covering IND filing at FDA, manufacture of clinical trial material and several human challenge studies to prove the efficacy of the vaccine.
ShigETEC is an orally administered vaccine candidate that induces broad protection against Shigella and Enterotoxigenic E. coli (ETEC), two major pathogens of diarrhoeal diseases among children under the age of five living in low- and middle-income countries, and affecting up to half of travellers to the developing world. Diarrhoeal diseases are also the top infectious-disease threats to military personnel deployed in endemic countries. ShigETEC is based on a live attenuated Shigella vaccine strain rationally designed to address the shortcomings of previous vaccine attempts and protects against both Shigella and ETEC.