DNA loop formation linked to Cornelia de Lange Syndrome

Healthy cells package their DNA with the help of proteins that fold it into loops. Scientists from the lab of Jan-Michael Peters at the IMP discovered that the formation of DNA loops can be impaired by mutations found in Cornelia de Lange Syndrome (CdLS), a neurodevelopmental disorder. The discovery may identify a main cause of the disorder and was now published in the journal PNAS.