Disrupting ribosome production – renewed potential for cancer therapy

Proliferating cells are in constant need of ribosomes, the molecular machines that help them produce proteins. Tumour cells, for instance, divide quickly and strongly rely on ribosome production to maintain their growth. A team of scientists including the IMP's David Haselbach has visualised a novel mechanism that inhibits the production of ribosomes in yeast.

The structure of Drg1 with the inhibitor diazaborine in side view (top) and top view (bottom). The AAA-domains are arranged around the open central pore. (Credit: IMP).