Cut to fit

Precise regulation of the innate immune response is critical in the fight against pathogens. A new study by Adrian Söderholm (Versteeg lab), published in Nucleic Acids Research, reveals how cells regulate immune signaling by controlling RNA processing of JAK2, a crucial signal transducer in mediating an innate immune response. The researchers identify the protein ERH as a previously underappreciated but essential factor in the interferon gamma (IFNγ) signaling pathway.