Cep97: a stabilizing protein roof for centrioles

Centrioles in human RPE cells examined by expansion microscopy. Left: Cep97 (purple) forms a stable cap at the distal end of fully grown centrioles (acetlyated tubulin, green) Right: Cep97 is lost as centrioles form cilia. Scalebar is 2μm

The proposed function of the centriolar protein Cep97 has to be revised, a new study from the Dammerman lab shows. Rather than just limiting centriole elongation, Cep97 forms a protective roof that ensures that centrioles maintain their correct size once the proper length is reached. The findings are published in “Current Biology” and could help explain how centrioles maintain their size and stability through multiple cell divisions, often throughout the entire lifetime of an organism.

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