All Eyes on the Proteome

Sexual reproduction involves the formation of gametes, specialized male and female reproductive cells. Gamete formation involves a process called meiosis where DNA is segregated into daughter cells, each containing half the genomic content of the adult cells. In their study published in Developmental Cell, Joao Matos and his collaborators characterized the composition and phosphorylation status of the proteome during meiosis, using budding yeast as a model system. They found that sequential waves of protein expression and phosphorylation rewire the proteome to enable gametogenesis. They also discovered that mitochondrial enzymes, such as ATP synthase and Aldehyde dehydrogenase, are regulated by phosphorylation during gametogenesis.

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