To fight off the vast array of pathogens we encounter every day, our immune system has come up with genetic mechanisms to diversify pathogen-detecting antibodies. Antibodies can be grouped in various classes with different functions: for each class to be produced, the DNA segments that encode them must be rearranged through ‘Class Switch Recombination’. In a new study now published in the journal Molecular Cell, researchers in the lab of Rushad Pavri at the IMP use cutting-edge methods to investigate this process and revise a long-standing model.
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