A “DEEP-Clear” view of nervous system diversity

Insight into the nervous systems of axolotl, bristleworms, zebrafish and two squids (clockwise), generated using the new DEEP-Clear method. Composite image by Marko Pende, TU Wien.

Researchers from the lab of Florian Raible at the Max Perutz Labs and their collaborators have developed an improved tissue clearing and depigmentation method that will help scientists to apply advanced microscopy methods to larger model organisms. The approach, termed “DEEP-Clear” and published in the journal Science Advances, is expected to improve scientists’ ability to study and visualize the whole nervous systems of many different species.

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